Aristolactam I
CAS No. : 13395-02-3
(Synonyms: Aristololactam; Aristolactam)
| Size | Price | Stock |
|---|---|---|
| 1mg | $70 | In-stock |
| 5mg | $175 | In-stock |
| 10mg | $280 | In-stock |
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| Cat. No. : | HY-N2013 |
| M.Wt: | 293.27 |
| Formula: | C17H11NO4 |
| Purity: | >98 % |
| Solubility: | DMSO : 12.5 mg/mL (ultrasonic);H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) |
Aristolactam I is an AQP1 inhibitor and Aristolochic acid I metabolite. Aristolactam I can be isolated from Aristolochia plants. Aristolactam I downregulates Twist1 expression, increases E-cadherin expression, and activates the TGF-β/Smad signaling pathway. Aristolactam I has anticancer activity against breast cancer. Aristolactam I is nephrotoxic. Aristolactam I is mainly used in the study of breast cancer and kidney diseases such as renal interstitial fibrosis[1][2][3][4][5].
In Vitro:Aristolactam I (0-40 μM; 21-48 h) inhibits cell migration and invasion through regulation of Twist1 in MDA-MB-231 breast cancer cells[1].
Aristolactam I (2.5-10 μM; 48 h) enhances the tendency of HK-2 cells to transform from epithelial cells to fibroblast-like cells[2].
In Vivo:Aristolactam I (2.25-9 mg/kg; i.p.; 5 days) induces nephrotoxicity in Sprague-Dawley rats[5].
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