AU1235
CAS No. : 1338780-86-1
| Size | Price | Stock |
|---|---|---|
| 2mg | $132 | In-stock |
| 5mg | $264 | In-stock |
| 10mg | $396 | In-stock |
| 25mg | $720 | In-stock |
| 50mg | $1080 | In-stock |
| 100mg | $1620 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-101867 |
| M.Wt: | 324.34 |
| Formula: | C17H19F3N2O |
| Purity: | >98 % |
| Solubility: | DMSO : 25 mg/mL (ultrasonic) |
AU1235, an adamantyl urea, is a potent MmpL3 inhibitor. The Mycobacterium tuberculosis protein MmpL3 performs an essential role in cell wall synthesis, since it effects the transport of trehalose monomycolates across the inner membrane[1][2]. In Vitro: AU1235 is similarly active against MDR isolates of M. tb displaying resistance to isoniazid, rifampicin, and pyrazinamide in addition to streptomycin, fluoroquinolones and/or ethambutol. AU1235 also inhibits Mycobacterium smegmatis and Mycobacterium fortuitum although the MICs (3.2 to 6.4 μg/ml) are significantly higher than against M. tb and M. bovis BCG[2].
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