OTS964 (hydrochloride)
CAS No. : 1338545-07-5
| Size | Price | Stock |
|---|---|---|
| 5mg | $110 | In-stock |
| 10mg | $165 | In-stock |
| 25mg | $275 | In-stock |
| 50mg | $495 | In-stock |
| 100mg | $825 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-12467 |
| M.Wt: | 428.97 |
| Formula: | C23H25ClN2O2S |
| Purity: | >98 % |
| Solubility: | H2O : 2 mg/mL (ultrasonic;warming;heat to 60°C);DMSO : ≥ 83.33 mg/mL |
OTS964 hydrochloride is an orally active, high affinity and selective TOPK (T-lymphokine-activated killer cell-originated protein kinase) inhibitor with an IC50 of 28 nM[1]. OTS964 hydrochloride is also a potent inhibitor of the cyclin-dependent kinase CDK11, which binds to CDK11B with a Kd of 40 nM[2].
IC50 & Target: IC50: 28 nM (TOPK)[1]
Kd: 40 nM (CDK11B)[2]
In Vitro: OTS964 hydrochloride (10 nM; 48 hours) suppresses cancer cell proliferation[1].
OTS964 hydrochloride (10 nM; 48 hours) increases cancer cell death[1].
OTS964 (0.1-2 μM; 24 and 48 hours) increases the expression of LC3-II and decreases the expression of P62, both in a dose-dependent manner[3].
In Vivo: OTS964 hydrochloride (intravenously; 40 mg/kg on days 1, 4, 8, 11, 15, and 18) makes tumors shrinking even after the treatment and finally revealing complete regression[1].
OTS964 hydrochloride (oral administration; 50 or 100 mg/kg/day for 2 weeks) ultimately achieves complete tumor regression[1].
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