OTS964
CAS No. : 1338542-14-5
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| Cat. No. : | HY-19718 |
| M.Wt: | 392.51 |
| Formula: | C23H24N2O2S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
OTS964 is an orally active, high affinity and selective TOPK inhibitor with an IC50 of 28 nM[1]. OTS964 is also a potent inhibitor of the cyclin-dependent kinase CDK11, which binds to CDK11B with a Kd of 40 nM[2].
IC50 & Target: IC50: 28 nM (TOPK)[1]
Kd: 40 nM (CDK11B)[2]
In Vitro: OTS964 (10 nM; 48 hours) suppresses cancer cell proliferation[1].
OTS964 (10 nM; 48 hours) increases cancer cell death[1].
OTS964 (0.1-2 μM; 24 and 48 hours) increases the expression of LC3-II and decreases the expression of P62, both in a dose-dependent manner[3].
In Vivo: OTS964 (intravenously; 40 mg/kg on days 1, 4, 8, 11, 15, and 18) makes tumors shrinking even after the treatment and finally revealing complete regression[1].
OTS964 (oral administration; 50 or 100 mg/kg/day for 2 weeks) achieves complete tumor regression[1].
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