OTS514
CAS No. : 1338540-63-8
| Size | Price | Stock |
|---|---|---|
| 2mg | $115 | In-stock |
| 5mg | $190 | In-stock |
| 10mg | $300 | In-stock |
| 25mg | $530 | In-stock |
| 50mg | $730 | In-stock |
| 100mg | $997 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-18621 |
| M.Wt: | 364.46 |
| Formula: | C21H20N2O2S |
| Purity: | >98 % |
| Solubility: | DMSO : 90 mg/mL (ultrasonic;adjust pH to 3 with 1M HCl) |
OTS514 is a highly potent TOPK inhibitor with an IC50 of 2.6 nM. OTS514 strongly suppresses the growth of TOPK-positive cancer cells[1]. OTS514 induces cell cycle arrest and apoptosis[2]. IC50 & Target:IC50: 2.6 nM (TOPK)[1] In Vitro: OTS514 (1.5625-100 nM) induces cell cycle arrest and apoptosis at nanomolar concentrations in a series of human myeloma cell lines (HMCL) and prevents outgrowth of a putative CD138+ stem cell population from multiple myeloma (MM) patient-derived peripheral blood mononuclear cells[2]. In Vivo: OTS514 (1-5 mg/kg; once a day for 2 weeks; intravenous administration) induces tumor regression in a xenograft model of A549 cells (TOPK-positive lung cancer cells)[1].
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- OTS514
- Cat. No.:
- HY-18621
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