Nevanimibe hydrochloride
CAS No. : 133825-81-7
(Synonyms: PD-132301 hydrochloride; ATR101 hydrochloride)
| Size | Price | Stock |
|---|---|---|
| 5mg | $260 | In-stock |
| 10mg | $360 | In-stock |
| 50mg | $730 | In-stock |
| 100mg | $950 | In-stock |
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| Cat. No. : | HY-100399A |
| M.Wt: | 458.08 |
| Formula: | C27H40ClN3O |
| Purity: | >98 % |
| Solubility: | DMSO : 41.67 mg/mL (ultrasonic);H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) |
Nevanimibe hydrochloride (PD-132301 hydrochloride) is an orally active and selective acyl-coenzyme A:cholesterol O-acyltransferase 1 (ACAT1) inhibitor with an EC50 of 9 nM. Nevanimibe hydrochloride inhibits ACAT2 with an EC50 of 368 nM. Nevanimibe hydrochloride induces cell apoptosis and has the potential for adrenocortical cancer[1]. In Vitro: Coincubation of Nevanimibe hydrochloride (PD-132301 hydrochloride; ATR101 hydrochloride; 3 nM-30 μM) and Cholesterol markedly increases toxicity in a dose-dependent manner, where 3 nM Nevanimibe in the presence of 60 μg/mL Cholesterol reduces survival by 60% after 24 hours. All doses of Nevanimibe (3 nM-30 μM) induces cytoxicity in the presence of Cholesterol, whereas treatment with Cholesterol in the absence of Nevanimibe has no effect on cell viability[1].
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