BMS-5
CAS No. : 1338247-35-0
(Synonyms: LIMKi 3)
| Size | Price | Stock |
|---|---|---|
| 1mg | $47 | In-stock |
| 5mg | $95 | In-stock |
| 10mg | $154 | In-stock |
| 25mg | $295 | In-stock |
| 50mg | $495 | In-stock |
| 100mg | $825 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-18305 |
| M.Wt: | 431.29 |
| Formula: | C17H14Cl2F2N4OS |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 34 mg/mL |
BMS-5 (LIMKi 3) is a potent LIMK inhibitor with IC50s of 7 nM and 8 nM for LIMK1 and LIMK2, respectively. IC50 & Target:IC50: 7 nM (LIMK1), 8 nM (LIMK2)[1] In Vitro: BMS-5 (LIMKi 3) inhibits cofilin-Ser3 phosphorylation in a dose-dependent manner in Nf2ΔEx2 mouse Schwann cells (MSCs) with an IC50 of ~2 μM. BMS-5 (LIMKi 3) reduces Nf2ΔEx2 MSC viability in a dose-dependent manner with an IC50 of 3.9 μM, but does not significantly reduce the viability of control Nf2flox2/flox2 MSCs at equivalent BMS-5 concentrations. At 10 μM BMS-5, Nf2ΔEx2 MSC viability is 40% compared to 83% for controls[2]. In Vivo: BMS-5 (LIMKi 3) (20 or 200 μM/side) is bilaterally infused into the hippocampus of rats immediately after contextual fear conditioning training. Rats are tested for memory consolidation 48 h after fear conditioning. Post hoc analysis shows that the group treated with 200 μM BMS-5 express lower freezing levels compared to the 20 μM and vehicle groups (P<0.01)[3].
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