(E/Z)-Locostatin
CAS No. : 133812-16-5
(Synonyms: (E/Z)-UIC-1005)
| Size | Price | Stock |
|---|---|---|
| 5mg | $50 | In-stock |
| 10mg | $75 | In-stock |
| 25mg | $140 | In-stock |
| 50mg | $210 | In-stock |
| 100mg | $305 | In-stock |
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| Cat. No. : | HY-W013411 |
| M.Wt: | 245.27 |
| Formula: | C14H15NO3 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
(E/Z)-Locostatin ((E/Z)-UIC-1005) is a racemic of Locostatin. Locostatin (UIC-1005) is a potent RKIP inhibitor. Locostatin binds Raf kinase inhibitor RKIP protein and disrupts the interaction of RKIP with Raf-1 kinase and G protein-coupled receptor kinase 2. Locostatin inhibits cell proliferation and migration. Locostatin aggravates thioacetamide (HY-Y0698)-induced acute liver failure in mice [1][2][3]. IC50 & Target:RKIP[3]
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