ATI-2341
CAS No. : 1337878-62-2
| Size | Price | Stock |
|---|---|---|
| 1mg | $140 | In-stock |
| 5mg | $320 | In-stock |
| 10mg | $450 | In-stock |
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| Cat. No. : | HY-P0172 |
| M.Wt: | 2256.82 |
| Formula: | C104H178N26O25S2 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
ATI-2341 is a potent and functionally selective allosteric agonist of C-X-C chemokine receptor type 4 (CXCR4), which functions as a biased ligand, favoring Gαi activation over Gα13. ATI-2341 activates the inhibitory heterotrimeric G protein (Gi) to promote inhibition of cAMP production and induce calcium mobilization. ATI-2341 is a potent and efficacious mobilizer of bone marrow polymorphonuclear neutrophils (PMNs) and hematopoietic stem and progenitor cells (HSPCs)[1][2]. IC50 & Target:CXCR4[1] In Vitro: ATI-2341 induces CXCR4- and G protein-dependent signaling, receptor internalization, and chemotaxis in CXCR4-expressing cells. ATI-2341 has an EC50 value of 194 ± 16 nM and an intrinsic activity of 81 ± 4% in CCRF-CEM cells[2].
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