R 80123
CAS No. : 133718-30-6
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| 1mg | $80 | In-stock |
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| Cat. No. : | HY-100615A |
| M.Wt: | 459.54 |
| Formula: | C26H29N5O3 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
R 80123 is the Z-isomer of R 79595, is also a highly selective phosphodiesterase inhibitor. The fuction is similar to R 80122 (HY-100615, Revizinone). In vivo: The administration of Revizinone improved the haemodynamic profile with an increase in cardiac output, a decrease in systemic vascular resistance and a stable heart rate and mean arterial blood pressure. [1] With regard to reconstitution of contractility and cardiac function Revizinone (E-isomer) is 10 fold more potent than R 79595 and nearly 100 fold more potent than R 80123 (Z-isomer). [2] Revizinone significantly increases global LV function and systolic wall thickening in ischemic areas at doses greater than or equal to 0.16 mg/kg i.v. [3]
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