AG-494
CAS No. : 133550-35-3
(Synonyms: Tyrphostin AG 494)
| Size | Price | Stock |
|---|---|---|
| 5mg | $26 | In-stock |
| 10mg | $45 | In-stock |
| 25mg | $90 | In-stock |
| 50mg | $145 | In-stock |
| 100mg | $250 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-101042 |
| M.Wt: | 280.28 |
| Formula: | C16H12N2O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
AG-494 (Tyrphostin AG 494) is a potent and selective EGFR tyrosine kinase inhibitor (IC50=0.7 μM). AG-494 inhibits the autophosphorylation of EGFR, ErbB2, HER1-2 and PDGF-R with IC50s 1.1, 39, 45 and 6 μM, respectively. AG-494 blocks Cdk2 activation and inhibits EGF-dependent DNA synthesis[1][2][3].
In Vitro: In DHER-14 cells, AG 494 inhibits Cdk2 activation and EGF-dependent DNA synthesis[2].
AG-494 significantly prevents NF-kB activation in silica-stimulated cells, and also reduces NF-kB activation in H2O2-treated cells[4].
AG-494 (3-9 μM; 5-7 days) inhibits BMP9-induced ALP activity in a dose-dependent manner[5].
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