KPT-185
CAS No. : 1333151-73-7
| Size | Price | Stock |
|---|---|---|
| 5mg | $60 | In-stock |
| 10mg | $94 | In-stock |
| 50mg | $259 | In-stock |
| 100 mg | Get quote | |
| 200 mg | Get quote | |
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| Cat. No. : | HY-15611 |
| M.Wt: | 355.31 |
| Formula: | C16H16F3N3O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic);Ethanol : 50 mg/mL (ultrasonic) |
KPT-185 is an orally bioavailable and selective inhibitor of CRM1 and displays potent antiproliferative properties at submicromolar concentrations (IC50=100-500 nM), induces apoptosis, cell-cycle arrest, and myeloid differentiation in AML cell lines and patient blasts.
IC50 & Target:CRM1[1]
In Vitro: KPT-185 (1-1000 nM; 72 hours) dramatically reduces HPB-ALL, Jurkat, CCRF-CEM, MOLT-4, KOPTK1, LOUCY cells growth with IC50s of 16-395 nM[4].
KPT-185 leads to cell cycle arrest in G1 phase in the MOLT-4 cell line[4].
KPT-185 results in a significant decrease in the level of CRM1 protein and a significant accumulation of p53 in the nucleus of MV4-11 and OCI-AML3 cells[1].
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