Fosifloxuridine nafalbenamide
CAS No. : 1332837-31-6
(Synonyms: NUC-3373)
| Size | Price | Stock |
|---|---|---|
| 5mg | $200 | In-stock |
| 10mg | $280 | In-stock |
| 25mg | $500 | In-stock |
| 50mg | $700 | In-stock |
| 100mg | $980 | In-stock |
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| Cat. No. : | HY-109115 |
| M.Wt: | 613.53 |
| Formula: | C29H29FN3O9P |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Fosifloxuridine nafalbenamide (NUC-3373), a pyrimidine nucleotide analogue, is a Thymidylate synthase inhibitor. Fosifloxuridine nafalbenamide has anticancer activity. Fosifloxuridine nafalbenamide has the potential to evoke a host immune response and enhance immunotherapy[1][2].
In Vitro: Fosifloxuridine nafalbenamide induces the release of damage-associated molecular patterns (DAMPs), with increased expression of calreticulin (CRT) at the cell surface and concomitant loss of nuclear nuclear high mobility group box protein 1 (HMGB1)[1].
In Vivo: Fosifloxuridine nafalbenamide exhibits anti-cancer activity in HT-29 nude mouse xenograft models[2].
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