GR-73632


CAS No. : 133156-06-6

133156-06-6
Price and Availability of CAS No. : 133156-06-6
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Cat. No. : HY-P1192
M.Wt: 766.00
Formula: C40H59N7O6S
Purity: >98 %
Solubility: H2O : 1 mg/mL (ultrasonic);DMSO : ≥ 100 mg/mL
Introduction of 133156-06-6 :

GR-73632 is a tachykinin NK1 receptor agonist. GR-73632 activates spinal NK1 receptors to induce scratching, biting and licking behaviors. GR-73632 activates peripheral NK1 receptors to trigger lacrimation in guinea pigs, and activates central NK1 receptors to induce repetitive hind paw tapping behavior in gerbils. GR-73632 is applicable to research related to pruritus[1][2][3]. IC50 & Target:IC50: NK-1 receptor[1] In Vivo:GR-73632 (0.1-2.5 pM; intrathecal injection; single administration) acts as a potent spinal NK1 receptor agonist in mice, and induces a dose-dependent syndrome of scratching, biting and licking behaviors[1].
GR-73632 (10-200 nM; intradermal injection; single administration) induces a dose-dependent scratching behavioral response in Mongolian gerbils[2].

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