(+)-N-Allylnormetazocine (hydrochloride)
CAS No. : 133005-41-1
(Synonyms: (+)-SKF 10047 (hydrochloride); (+)-N-Allyl-N-normetazocine (hydrochloride))
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| Cat. No. : | HY-101376 |
| M.Wt: | 293.83 |
| Formula: | C17H24ClNO |
| Purity: | >98 % |
| Solubility: | H2O : 100 mg/mL (ultrasonic) |
(+)-N-Allylnormetazocine ((+)-SKF 10047) hydrochloride is a benzomorphan opioid with psychotomi metic effects. (+)-N-Allylnormetazocine hydrochloride is an opioid receptor antagonist with Ki values of 300 nM and 27 μM for σ1 and σ2 opioid receptors, respectively. (+)-N-Allylnormetazocine hydrochloride can be used for the research of neurological disease[1][2]. In Vitro:(+)-N-Allylnormetazocine hydrochloride (1 nM) inhibits µ, δ and κ opioid receptors of 28.5%, 2.5% and 31%, respectively[1]. (+)-N-Allylnormetazocine hydrochloride shows Ki values of 300 nM and 27 μM for σ1 and σ2 opioid receptors[1]. In Vivo:(+)-N-Allylnormetazocine hydrochloride (0.3, 1, 3 , 10 and 30 mg/kg; intraperitoneal injection, 10 minutes before each session) dose-dependently increases the response made on the lever appropriate for dissociative anesthetics phencyclidine (PCP) in rats with PCP or saline[2].
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