Uridine 5′-diphosphoglucose

Uridine 5’-diphosphoglucose (UDP-glucose), secreted by cardiomyocytes during ischemia and reperfu, is a potent agonist of the proinflammatory P2Y14 receptor. It acts an important role in the regulation of inflammation and neutrophil polarization in neutrophils. Uridine 5’-diphosphoglucose is also the precursor of glucose-containing oligosaccharides, polysaccharides, glycoproteins, and glycolipids in animal tissues and in some microorganisms. Uridine 5’-diphosphoglucose is promising for research in counteracting myocardial infarction/reperfusion (MIR)-induced inflammation in the heart tissue^[1][2][3][4].
In Vitro:Uridine 5’-diphosphoglucose (0-100 μM, 24 h) upregulates the expression of P2Y14 receptor, which induces neutrophil apoptos^[2].
Uridine 5’-diphosphoglucose (1 μM, 24 h) and PPTN (HY-110322A) result in suppressed mRNA level of inflammatory factors including CCL3, IL1β,IL12a, TNF-α in neutrophils compared to cells treated with Uridine 5’-diphosphoglucose disodium salt alone, on the contrary, anti-inflammatory factors including IL10, TGF-β1, YM1 are upregulated upon Uridine 5’-diphosphoglucose disodium salt and PPTN (HY-110322A) in neutrophils^[2].
Depletion of the pools of uridine 5’-diphosphoglucose (5 or 20 mM, incubation for 3 h) in the liver of the rat was associated with decreased glycosylation of secreted and tissue glycoproteins, influencing the rate of glomerular basement membrane (GBM) synthesis in rats^[3].