4-Aminosalicylic acid (hemicalcium)
CAS No. : 133-15-3
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| Cat. No. : | HY-22252 |
| M.Wt: | 173.18 |
| Formula: | C7H7NO3.1/2Ca |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
4-Aminosalicylic acid hemicalcium is an inhibitor for dihydrofolate reductase (DHFR) and an antituberculous agent. 4-Aminosalicylic acid hemicalcium exhibits anti-inflammatory activity and can be used in research of inflammatory bowel disease (IBD). 4-Aminosalicylic acid hemicalcium is orally active[1][1][3].
In Vitro:4-Aminosalicylic acid hemicalcium is incorporated into the folate pathway via dihydropteroate synthase (DHPS) and dihydrofolate synthase (DHFS) to generate the hydroxydihydrofolate antimetabolite, which in turn inhibits DHFR enzyme activity[1].
4-Aminosalicylic acid hemicalcium inhibits M. tuberculosis H37Rv growth with MIC value of 0.4 μM[1].
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- 4-Aminosalicylic acid (hemicalcium)
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