Glucokinase activator 1
CAS No. : 1328987-85-4
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| Cat. No. : | HY-101788 |
| M.Wt: | 586.58 |
| Formula: | C27H20F2N2O7S2 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Glucokinase activator 1 is a liver-directed glucokinase activator with an EC50 of 34 nM. IC50 & Target: EC50: 34 nM (Glucokinase)[1] In Vivo: Glucokinase activator 1 (3 to 300 mg/kg, oral, 180 minutes) shows a dose dependent improvement in glucose excursion in oGTT in a DIO mouse model of T2D. The predominant liver-directed tissue distribution of Glucokinase activator 1 ensures a good safety window with respect to hypoglycemia over a 10-fold dose range[1].
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