STL127705
CAS No. : 1326852-06-5
| Size | Price | Stock |
|---|---|---|
| 5mg | $197 | In-stock |
| 10mg | $295 | In-stock |
| 25mg | $497 | In-stock |
| 50mg | $740 | In-stock |
| 100mg | $970 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-122727 |
| M.Wt: | 437.42 |
| Formula: | C22H20FN5O4 |
| Purity: | >98 % |
| Solubility: | H2O : < 0.1 mg/mL (ultrasonic);DMSO : < 1 mg/mL |
STL127705 (Compound L) is a potent Ku 70/80 heterodimer protein inhibitor with an IC50 of 3.5 μM. STL127705 interferes the binding of Ku70/80 to DNA and by inhibits the activation of the DNA-PKCS kinase. STL127705 shows antiproliferative and anticancer activity. STL127705 induces apoptosis[1][2].
IC50 & Target:IC50: 3.5 μM (Ku 70/80), 2.5 μM (DNA-PKCS)[1]
In Vitro:STL127705 (Compound L) (0-100 μM) inhibits binding of Ku70/80 to a DNA substrate and inhibits Ku-dependent activation of the DNA-PKCS kinase[1].
STL127705 (0-100 μM; 6h) decreases the expression of DNA-PKCS auto-phosphorylation in SF-767 cells[1].
STL127705 (0-40 μM; 6h) shows antiproliferative activity in a dose dependent manner[1].
TL127705 (1 μM; 48 h) significantly promotes apoptotic when combination with gemcitabine[2].
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