HNMPA
CAS No. : 132541-52-7
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| Cat. No. : | HY-101962 |
| M.Wt: | 238.18 |
| Formula: | C11H11O4P |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
HNMPA is a membrane impermeable insulin receptor tyrosine kinase inhibitor. HNMPA inhibits serine and tyrosine autophosphorylation by the human insulin receptor. HNMPA has no effect on protein kinase C or cyclic AMP-dependent protein kinase activities[1][2]
In Vitro: HNMPA inhibits the phosphorylation of a synthetic peptide substrate composed of insulin receptor residues 1290-1319 on serines-1305/1306 by partially purified insulin receptors[1].
HNMPA blocks GABA-dependent insulin inhibition, and reduces neuronal firing after GABA application[2].
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