Alosetron (Hydrochloride(1:X))
CAS No. : 132414-02-9
(Synonyms: GR 68755 (Hydrochloride(1:X)); GR 68755X (Hydrochloride(1:X)))
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| Cat. No. : | HY-70050 |
| M.Wt: | 1000.00 |
| Formula: | C17H18N4O.xClH |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Alosetron (GR 68755) Hydrochloride(1:X) is a potent and highly selective serotonin 5-HT3 receptor antagonist. Alosetron Hydrochloride(1:X) is used for the research of irritable bowel syndrome (IBS). Alosetron Hydrochloride(1:X) blocks the fast 5HT3-mediated depolarisation of guinea-pig myenteric and submucosal neurons, with IC50 at ~55 nM. Alosetron Hydrochloride(1:X) attenuates the visceral nociceptive effect of rectal distension in conscious or anaesthetised dogs. Anti-inflammatory effects[1][2]. In Vivo: Dexamethasone and Alosetron-treated (1 mg/kg; ip; daily for 6 days) rats exhibits a significant decrease in the diarrhea index, in comparison with TNBS-control group, especially after the initial 2 days of treatment following the induction of colitis[2].
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