Tryptanthrin
CAS No. : 13220-57-0
| Size | Price | Stock |
|---|---|---|
| 5mg | $50 | In-stock |
| 10mg | $85 | In-stock |
| 25mg | $160 | In-stock |
| 50mg | $255 | In-stock |
| 100mg | $335 | In-stock |
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| Cat. No. : | HY-N6607 |
| M.Wt: | 248.24 |
| Formula: | C15H8N2O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 7.14 mg/mL (ultrasonic) |
Tryptanthrin is an indole quinazoline that could be an alkaloid from indigo-bearing plants. Tryptanthrin is a potent and orally active cellular Leukotriene (LT) biosynthesis inhibitor. Tryptanthrin has anticancer activity. Tryptanthrin suppresses the expression levels of NOS1, COX-2, and NF-κB and regulates the expression levels of IL-2, IL-10, and TNF-α[1][2].
IC50 & Target:IC50: 10 µM (LT formation in human whole blood)[1]
In Vitro:Tryptanthrin (0-60 μM; 24, 48 and 72 h) inhibits the proliferation and colony formation of MCF-7 cells[1].
Tryptanthrin (6.25-25 μM; 48 h; MCF-7 cells) reverses EMT-associated E-cadherin, MMP-2 and Snail[1].
Tryptanthrin (0-30 μM; 15 min; MCF-7 cells) reduces Leukotriene (LT)-formation in human neutrophils with an IC50 value of 0.6 µM[2].
In Vivo:Tryptanthrin (25-100 mg/kg; i.g.; daily, for 13 d; Female Bal b/c mice with 4T1 xenograft) inhibits tumor growth and regulates IL-2, IL-6, IL-10, IL-12 and TNF-α levels in tumor-bearing mice[1].
Tryptanthrin (10 mg/kg; p.o.; male Wistar Han rats) inhibits LTB4 formation in vivo[2].
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