Ramosetron
CAS No. : 132036-88-5
(Synonyms: YM060 (free base))
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| Cat. No. : | HY-A0274 |
| M.Wt: | 279.34 |
| Formula: | C17H17N3O |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Ramosetron (YM060 free base) is an orally active 5-HT3 antagonist that improves dysphoria, interference with activity and food avoidance. Ramosetron is promising for research of irritable bowel syndrome with diarrhea[1][2][3][4]. In Vitro:Ramosetron (1 μM) inhibits 5-HT3 receptor-dependent 5-HT release in guinea pig colonic mucosa[3]. In Vivo:Ramosetron (0.01-0.1 mg/kg, p.o., twice daily for 5 days) Ameliorates 5-fluorouracil (5-FU) (HY-90006)-induced intestinal mucositis in C57BL/6 mice[2].
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