UNC 0631
CAS No. : 1320288-19-4
| Size | Price | Stock |
|---|---|---|
| 5mg | $120 | In-stock |
| 10mg | $190 | In-stock |
| 25mg | $380 | In-stock |
| 50mg | $610 | In-stock |
| 100 mg | Get quote | |
| 200 mg | Get quote | |
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| Cat. No. : | HY-13808 |
| M.Wt: | 635.93 |
| Formula: | C37H61N7O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 16.67 mg/mL (ultrasonic);Ethanol : 100 mg/mL (ultrasonic);DMF : 150 mg/mL (ultrasonic) |
UNC 0631 is a potent histone methyltransferase G9a inhibitor with an IC50 of 4 nM. UNC 0631 potently reduces H3K9me2 levels in MDA-MB-231 cells with an IC50 of 25 nM[1]. In Vitro: UNC 0631 (Compound 7) has high cellular potency and excellent separation of functional potency versus cell toxicity in a variety of cell lines. UNC 0631 is highly potent in reducing H3K9me2 levels and has low cell toxicity. UNC 0631 reduces H3K9me2 levels with ICW IC50 values of 25 nM, 18 nM, 26 nM, 24 nM, 51 nM, 72 nM and 46 nM in MDA-MB-231, MCF7, PC3, 22RV1, HCT116 wt, HCT 116 p53-/- and IMR90 cell lines, respectively[1].
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- HY-13808
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