T808
CAS No. : 1320211-61-7
| Size | Price | Stock |
|---|---|---|
| 1mg | $400 | In-stock |
| 5mg | $1020 | In-stock |
| 10mg | $1430 | In-stock |
| 25mg | $2290 | In-stock |
| 50mg | $3210 | In-stock |
| 100mg | $4490 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-101185 |
| M.Wt: | 298.36 |
| Formula: | C17H19FN4 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
T808 is a selective tau protein-targeting ligand. T808 can be used to synthesize [18F]-T808, a highly selective tau protein positron emission tomography (PET) tracer. T808 can also be used to synthesize [3H]-T808, a marker for in vitro experiments. T808 can be used for the research of alzheimer’s disease[1][2].
In Vitro:T808 (10 μM; 120 min; mouse liver microsomes assay) is rapidly metabolized in the presence of NADPH, while 85% remains intact after 2 h incubation without NADPH[2].
T808 (10 μM; 120 min; human liver microsomes assay) is more metabolically stable, with 30% remaining intact after 2 h incubation with NADPH and over 93% intact without NADPH[2].
T808 (1 μM, 3 μM) shows no significant inhibition against 72 common CNS targets, with only weak inhibition on norepinephrine transporter 1 (IC50 = 0.82 μM) and monoamine transporter (IC50 = 2.7 μM)[2].
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