Dibenzothiophene
CAS No. : 132-65-0
(Synonyms: DBT; Diphenylene sulfide)
| Size | Price | Stock |
|---|---|---|
| 25g | $14 | In-stock |
| 100g | $45 | In-stock |
| 500g | $134 | In-stock |
| 1000g | $202 | In-stock |
| > 2 kg | Get quote | |
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| Cat. No. : | HY-B0973 |
| M.Wt: | 184.26 |
| Formula: | C12H8S |
| Purity: | >98 % |
| Solubility: | DMSO : 75 mg/mL (ultrasonic;warming;heat to 60°C) |
Dibenzothiophene is an orally active and a noncompetitive CYP1A inhibitor. Dibenzothiophene inhibits CYP1A-mediated EROD activity with a Km of 0.592 μM. Dibenzothiophene interacts with the AHR pathway. Dibenzothiophene enhances the embryotoxicity of β-naphthoflavone (HY-114740). Dibenzothiophene shows acute toxicity in mice. Dibenzothiophene is mainly used for the study of the mechanism of developmental toxicity in organisms[1][2].
IC50 & Target:Km: 0.592 μM for EROD
In Vitro:Dibenzothiophene (0-100 μM) inhibits Ethoxyresorufin-O-deethylase (EROD) activity in β-naphthoflavone-induced channel catfish microsomes[1].
In Vivo:Dibenzothiophene (10-500 μg/L) reduces in ovo EROD activity in killifish (Fundulus heteroclitus) embryos in a dose-dependent manner and enhances the embryotoxicity of β-naphthoflavone[1].
Dibenzothiophene (215-744 mg/kg; p.o., via esophageal tube, once) shows acute toxicity in male CD-1 mice[2].
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