Dexbrompheniramine

Dexbrompheniramine ((+)-Brompheniramine; (S)-Brompheniramine) is a dual inhibitor of histamine H1 receptor and TRPV1 receptor that can cross the blood-brain barrier. Dexbrompheniramine exerts its effects by functionally blocking H1 receptor activity and dose-dependently inhibiting TRPV1-mediated calcium responses, including Capsaicin (HY-10448)-induced responses. The combination of Dexbrompheniramine with Cimetidine (HY-14289) eliminates histamine-induced and sham-feeding-induced drinking behavior, whereas Dexbrompheniramine alone does not induce thirst or alter sham-feeding behavior in rats. Dexbrompheniramine can be used in the research of chronic cough and related pathological mechanisms^[1][2][3]. In Vivo:Dexbrompheniramine (1 mg/kg; i.p.; single dose; co-administered with 16 mg/kg cimetidine) completely abolishes histamine-induced drinking behavior in rats, but does not alter serotonin-induced drinking behavior in rats^[1].
Dexbrompheniramine (1 mg/kg; i.p.; single administration; 10 min before the start of the test) alone does not alter prandial drinking or sham-feeding behavior in preabsorptive rats, but when co-administered with 16 mg/kg cimetidine, it completely abolishes the drinking response without affecting sham-feeding behavior^[3].