Lexacalcitol
CAS No. : 131875-08-6
(Synonyms: KH1060)
| Size | Price | Stock |
|---|---|---|
| 5mg | $640 | In-stock |
| 10mg | $1024 | In-stock |
| 25mg | $2150 | In-stock |
| 50mg | $3440 | In-stock |
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| Cat. No. : | HY-32340 |
| M.Wt: | 460.69 |
| Formula: | C29H48O4 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Lexacalcitol (KH1060), a vitamin D analog, is a potent regulator of cell growth and immune responses. Lexacalcitol can be used for the research of graft rejection, psoriasis, cancer and auto-immune diseases[1][2].
In Vitro: Lexacalcitol inhibits cell proliferation by 50% at 10-12 M (14,000 times more active than la,25(OH)2D3) in human histiocytic lymphoma cell line U 937[1].
Lexacalcitol inhibits interleukin-1-induced mouse thymocyte proliferation by 50% at 3×10-16 M , allogeneic stimulation of mouse spleen lymphocytes at 5×10-15 M[1].
In Vivo: Lexacalcitol (0.5 mg/kg/2 days; i.p.) in combination with cyclosporin A (CyA) can prevent autoimmune destruction of syngeneic islet grafts in spontaneously diabetic NOD recipients[2].
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