Azoxystrobin

Azoxystrobin is an orally active, broad-spectrum β-methoxyacrylate fungicide. Azoxystrobin inhibits mitochondrial respiration by binding to the Qo site of the cytochrome bc1 complex and inhibiting electron transfer. Azoxystrobin induces the production of reactive oxygen species (ROS) and induces cell apoptosis^[1][2][3][4]. In Vitro:Azoxystrobin (1, 5, 25 mg/L, 1 hour) significantly reduces the germination rate of C. macrocarpum spores and the length of mycelial growth in a dose-dependent manner. Azoxystrobin exhibits inhibitory effects on C. macrocarpum^[2].
Azoxystrobin (25 mg/L, 1 hour) significantly delays the germination of A. alternata spores, reduces the final germination rate, and inhibits mycelial growth and papilla formation. Azoxystrobin demonstrates a clear inhibitory effect on A. alternata^[2].
In Vivo:Azoxystrobin (0.5, 1, 10 mg/kg; Azoxystrobin solution is mixed with dry oat and administered orally; twice a week; 21 days) has a dose effect on the bacterial and fungal communities in the gut of E. crypticus, inducing the growth of pathogens, reducing the abundance of beneficial bacteria and disrupting the stability of the gut microecology^[4].
Azoxystrobin (0, 2, 25, 50 mg/kg) inhibits the activity of urease, Invertase (HY-P2979), and phosphatase, and alters the relative abundance of soil microbial communities^[3].