Bisindolylmaleimide X
CAS No. : 131848-97-0
(Synonyms: BIM-X; Ro31-8425)
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| Cat. No. : | HY-108136 |
| M.Wt: | 424.49 |
| Formula: | C26H24N4O2 |
| Purity: | >98 % |
| Solubility: |
Bisindolylmaleimide X (Ro 31-8425, BIM-X) is a cell-penetrating PKC inhibitor. Bisindolylmaleimide X is a potent cyclin-dependent kinase 2 (CDK2) antagonist with an IC50 of 200 nM. Bisindolylmaleimide X inhibits the proliferation of CD4 T cells in vitro. Bisindolylmaleimide X inhibits eNOS-Ser1177 phosphorylation in human embryonic vein endothelial cells. Bisindolylmaleimide X can be used for research on the immune system and cardiovascular diseases[1][2][3].
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