CAS No. : 131740-09-5
(Synonyms: Alvocidib (Hydrochloride); L86-8275 (Hydrochloride); HMR-1275 (Hydrochloride))
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Cat. No. : | HY-10006 |
M.Wt: | 438.30 |
Formula: | C21H21Cl2NO5 |
Purity: | >98 % |
Solubility: | DMSO : ≥ 20 mg/mL (45.63 mM); DMF : 7.69 mg/mL (17.55 mM; Need ultrasonic); H2O : ≥ 20 mg/mL (45.63 mM) |
Flavopiridol Hydrochloride (Alvocidib Hydrochloride) is a broad inhibitor of CDK, competing with ATP to inhibit CDKs including CDK1, CDK2, CDK4 with IC50s of 30, 170, 100 nM, respectively. IC50 & Target: IC50: 30 nM (CDK1), 170 nM (CDK2), 100 nM (CDK4)[3] In Vitro: Flavopiridol (2 μM) robustly induces a distinct pattern of ER stress in CLL cells that contributes to cell death through IRE1-mediated activation of ASK1 and possibly downstream caspases[1]. Flavopiridol results in potent upregulation of a number of PRGs in treatments lasting 4-24 h. Flavopiridol has and immediate and long-term effect on the expression of several PRGs. In serum starved cells re-stimulated with serum, flavopiridol also inhibits the expression of these genes, but subsequently, JUNB, GADD45B and EGR1 are upregulated in the presence of flavopiridol[2].
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