Trimetazidine (dihydrochloride)
CAS No. : 13171-25-0
| Size | Price | Stock |
|---|---|---|
| 5mg | $25 | In-stock |
| 10mg | $30 | In-stock |
| 25mg | $45 | In-stock |
| 50mg | $60 | In-stock |
| 100mg | $102 | In-stock |
| 500mg | $230 | In-stock |
| 1g | $325 | In-stock |
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| 10 g | Get quote | |
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| Cat. No. : | HY-B0968 |
| M.Wt: | 339.26 |
| Formula: | C14H24Cl2N2O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 25 mg/mL (ultrasonic);H2O : ≥ 100 mg/mL |
Trimetazidine dihydrochloride is a selective long chain 3-ketoyl coenzyme A thiolase inhibitor with an IC50 of 75 nM, which can inhibit β-oxidation of free fatty acid (FFA). Trimetazidine dihydrochloride is an effective antianginal agent and a cytoprotective drug, has anti-oxidant, anti-inflammatory, antinociceptive and gastroprotective properties. Trimetazidine dihydrochloride triggers autophagy. Trimetazidine dihydrochloride is also a 3-hydroxyacyl-CoA dehydrogenase (HADHA) inhibitor[1][2][3][4].
IC50 & Target: IC50: 75 nM (long chain 3-ketoyl coenzyme A thiolase)[2]
β-oxidation[2]
Autophagy[3]
3-hydroxyacyl-CoA dehydrogenase (HADHA)[4]
In Vitro: Trimetazidine (1 μM-100 μM; 24 hours; HUVECs) could enhance the viability of the injured HUVECs induces by oxidation in a certain dose-dependent manner[1].
In Vivo: Trimetazidine (5-20 mg/kg; oral administration; 1 hour; Swiss albino male mice) in 10 mg/kg and 20 mg/kg doses significantly raises the seizure-threshold current in the increasing current electroshock seizure (ICES) test in the mice[5].
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