Olodanrigan (sodium)
CAS No. : 1316755-17-5
(Synonyms: EMA401 (sodium); PD-126055 (sodium))
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| Cat. No. : | HY-13106A |
| M.Wt: | 529.56 |
| Formula: | C32H28NNaO5 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Olodanrigan (EMA401) sodium is a highly selective, orally active, peripherally restricted angiotensin II type 2 receptor (AT2R) antagonist. Olodanrigan sodium is under development as a neuropathic pain therapeutic agent. Olodanrigan sodium analgesic action appears to involve inhibition of augmented AngII/AT2R induced p38 and p42/p44 MAPK activation, and hence inhibition of DRG neuron hyperexcitability and sprouting of DRG neurons[1][2][3][4].
IC50 & Target:"Reverse Transcriptase[1]
HIV[1]"
In Vivo: EMA401 sodium (10 mg/kg; p.o.) results in a significant attenuation of theta power and increase in paw withdrawal latencies (PWL) in rats at day 14 after chronic constriction injury (CCI)[4].
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