LM10
CAS No. : 1316695-35-8
| Size | Price | Stock |
|---|---|---|
| 10mg | $41 | In-stock |
| 25mg | $100 | In-stock |
| 50mg | $120 | In-stock |
| 100mg | $147 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-33298 |
| M.Wt: | 229.22 |
| Formula: | C11H8FN5 |
| Purity: | >98 % |
| Solubility: | H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C);DMSO : 50 mg/mL (ultrasonic) |
LM10 is a potent inhibitor of tryptophan 2,3-dioxygenase (TDO). Tryptophan 2,3-dioxygenase (TDO) is an unrelated hepatic enzyme that also degrades tryptophan along the kynurenine pathway. LM10 has the potential for the research of cancer diseases[1].
IC50 & Target:TDO[1]
In Vivo: LM10 (160 mg/kg; p.o.) prevents the growth of TDO-expressing P815 tumor cells and promotes better rejection of control clone P815B cl1, which does not express TDO[1].
LM10 displays a good TDO inhibition (Ki = 5.6 μM) with a competitive inhibition profile[1].
LM10 does not inhibit IDO and has a high solubility and bioavailability without obvious signs of toxicity[1].
The plasma concentration of LM10 after oral administration of 160 mg/kg/day is between 20 and 40 μg/mL (87-175 μM), a concentration about 40 times above the IC50 measured in the cellular assay performed with the physiological concentration of plasma tryptophan[1].
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