E-6123
CAS No. : 131614-02-3
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| Cat. No. : | HY-10164 |
| M.Wt: | 451.97 |
| Formula: | C23H22ClN5OS |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
E- 6123 is a platelet-activating factor (PAF) receptor antagonist. IC50 & Target: PAF[1] In Vitro: E-6123 (E6123) partially inhibits the Thapsigargin-induced increase in the levels of interleukin-6 mRNA and interleukin-6 protein. To clarify the role of the concurrently produced cell-associated PAF in the thapsigargin-induced increase in the interleukin-6 mRNA level and interleukin-6 production, the effects of the PAF receptor antagonist E-6123 are examined. E-6123 at 1 and 10 μM partially inhibits the Thapsigargin (46.1 nM)-induced increase in the interleukin-6 mRNA level at 4 h and interleukin-6 production at 8 h[1].
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