JAK1-IN-17
CAS No. : 1315490-71-1
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| Cat. No. : | HY-16641 |
| M.Wt: | 309.37 |
| Formula: | C17H19N5O |
| Purity: | >98 % |
| Solubility: |
JAK1-IN-17 (Compound 31) is a highly selective inhibitor of JAK1 with a Ki of 1.9 nM. JAK1-IN-17 exhibits a low whole blood shift, which allows maintaining good whole blood potency. JAK1-IN-17 is also a nitrile-containing analogue with consistent, yet weak reversible inhibition of CYP3A4 using a midazolam probe (IC50 = 7.9 μM). JAK1-IN-17 can be studied in cancer research[1].
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