Pep2-AVKI
CAS No. : 1315378-69-8
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| Cat. No. : | HY-P1059 |
| M.Wt: | 1268.46 |
| Formula: | C60H93N13O17 |
| Purity: | >98 % |
| Solubility: |
Pep2-AVKI is a selective peptide inhibitor of the binding of the AMPA receptor subunit (GluR2) at the C-terminal PDZ site to C-kinase (PICK1). Pep2-AVKI does not affect the binding of (AMPA-type glutamate receptor) GluA2 to GRIP or ABP. Pep2-AVKI does not increase the amplitude of AMPA currents. pep2-AVKI can be used to study neurological diseases[1][2][3][4]. In Vitro:Pep2-AVKI (1 mM) selectively binds to PICK and does not alter (Miniature Excitatory Postsynaptic Current) mEPSC amplitude or frequency, but inhibits the activity-induced increase in (Excitatory Postsynaptic Current) EPSC amplitude ratio in cerebellar stellate cells[1].
Pep2-AVKI (1 mM) blocks the increase in synaptic GluR2-containing receptors in cerebellar stellate cells[1].
Pep2-AVKI increases AMPA-evoked (radiolabeled norepinephrine) [3H]NA and (radiolabeled D-aspartate) [3H]D-ASP and increases 10 μM NMDA/1 μM Glycine (HY-Y0966)/50 μM (S) AMPA-induced tritium release, but does not alter 10 μM NMDA/1 μM Glycine-induced [3H]D-ASP release in hippocampal synaptosomes[2][3].
Pep2-AVKI (100 μM) blocks (Long-Term Depression) LTD in postsynaptic neurons[4].
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