NG25
CAS No. : 1315355-93-1
| Size | Price | Stock |
|---|---|---|
| 1mg | $98 | In-stock |
| 5mg | $150 | In-stock |
| 10mg | $248 | In-stock |
| 25mg | $540 | In-stock |
| 50mg | $846 | In-stock |
| 100mg | $1180 | In-stock |
| 500mg | $2380 | In-stock |
| 1g | $3800 | In-stock |
| 5 g | Get quote | |
| 10 g | Get quote | |
| We match the lowest price on market. | ||
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| Cat. No. : | HY-15434 |
| M.Wt: | 537.58 |
| Formula: | C29H30F3N5O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 16.67 mg/mL (ultrasonic;warming;heat to 60°C) |
NG25 is a potent dual TAK1 and MAP4K2 inhibitor, with IC50s of 149 nM and 21.7 nM, respectively. IC50 & Target:IC50: 21.7 nM (MAP4K2), 149 nM (TAK1), 12.9 nM (LYN), 56.4 nM (CSK)[1] In Vitro: NG25 is a potent dual TAK1 and MAP4K2 inhibitor, with IC50s of 149 nM and 21.7 nM, respectively. NG25 also potently suppresses several kinases such as LYN, CSK, FER, p38α, ABL,ARG and SRC, with IC50s of 12.9, 56.4, 82.3, 102, 75.2, and 113 nM, respectively[1]. NG25 is very potent suppressor of CpG B- or CpG A-stimulated secretion of IFNα and CL097-stimulated secretion of IFNβ, with complete inhibition by 400 nM[2]. NG25 treatment reduces cell viability of all tested breast cancer cell lines in a dose dependent manner. NG25 (2?μM) enhances the cytotoxic effect of Dox on breast cancer cells[3].
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