MARK-IN-2
CAS No. : 1314893-26-9
| Size | Price | Stock |
|---|---|---|
| 1mg | $300 | In-stock |
| 5mg | $670 | In-stock |
| 10mg | $1080 | In-stock |
| 25mg | $2150 | In-stock |
| 50mg | $3400 | In-stock |
| 100mg | $5500 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-101934 |
| M.Wt: | 425.88 |
| Formula: | C18H18ClF2N5OS |
| Purity: | >98 % |
| Solubility: | DMSO : 25 mg/mL (ultrasonic) |
MARK-IN-2 is a potent microtubule affinity regulating kinase (MARK) inhibitor with an IC50 of 5 nM. IC50 & Target:IC50: 5 nM (MARK)[1] In Vitro: MARK-IN-2 (Compound 27) is a potent MARK inhibitor. Inhibition of MARK represents a potentially attractive means of arresting neurofibrillary tangle pathology in Alzheimer's disease. MARK-IN-2 inhibits MARK3 with an IC50 of 5 nM. MARK-IN-2 also inhibits MARK3 in primary cell culture of rat cortical neurons with an IC50 of 280 nM[1]. In Vivo: Characterization of the i.v. pharmacokinetic properties of MARK-IN-2 in rat and dog reveals reasonable volumes of distribution but moderate to high clearance and short half-lives. MARK-IN-2 (Compound 27) has moderate terminal elimination half-life (t1/2=0.7 h, and 1 h for rat and dog) [1].
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