MMV390048


CAS No. : 1314883-11-8

1314883-11-8
Price and Availability of CAS No. : 1314883-11-8
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5mg $70 In-stock
10mg $110 In-stock
25mg $225 In-stock
50mg $380 In-stock
100mg $610 In-stock
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Cat. No. : HY-106005
M.Wt: 393.38
Formula: C18H14F3N3O2S
Purity: >98 %
Solubility: DMSO : 100 mg/mL (ultrasonic)
Introduction of 1314883-11-8 :

MMV390048 is a representative of a new chemical class of Plasmodium PI4K inhibitor (Kdapp=0.3 µM). MMV390048 binds to the ATP binding site of Plasmodium PI4K and does not bind to other P. falciparum and human kinases apart from human PIP4K2C, thus alleviating potential kinase-mediated safety concerns. MMV390048 is an antimalarial agent[1]. IC50 & Target:Kdapp: 0.3 µM (Plasmodium PI4K inhibitor)[1] In Vitro: MMV390048 against intraerythrocytic life cycle stages of P. falciparum (NF54 drug-sensitive strain) showed a steep inhibition curve with IC50 and IC90 values of 28 and 40 nM, respectively.

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