Bis-PEG2-PFP ester
CAS No. : 1314378-18-1
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| Cat. No. : | HY-112560 |
| M.Wt: | 538.29 |
| Formula: | C20H12F10O6 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Bis-PEG2-PFP ester is also a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Bis-PEG2-PFP ester is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2].
In Vitro: ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
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