MK2-IN-1 (hydrochloride)
CAS No. : 1314118-94-9
| Size | Price | Stock |
|---|---|---|
| 5mg | $65 | In-stock |
| 10mg | $110 | In-stock |
| 25mg | $240 | In-stock |
| 50mg | $385 | In-stock |
| 100mg | $580 | In-stock |
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| Cat. No. : | HY-12834A |
| M.Wt: | 509.43 |
| Formula: | C27H26Cl2N4O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic);H2O : ≥ 100 mg/mL |
MK2-IN-1 hydrochloride (compound 1) is a potent and selecitve MAPKAPK2 (MK2) inhibitor with an IC50 of 0.11 uM for MK2 and an EC50 of 0.35 uM for pHSP27. MK2-IN-1 hydrochloride impaires the phosphorylation level of serine residues in the Tfcp2l1 protein[1][2].
In Vitro:MK2-IN-1 (purchased from MCE; 5 μM; 0.5-8 h) hydrochloride gradually increases Tfcp2l1 protein level without a change in the Tfcp2l1 transcript level within 2 h[2].
MK2-IN-1 hydrochloride induces more alkaline phosphatase (AP)-positive colonies than the other factors in a short time[2].
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