Periplocin
CAS No. : 13137-64-9
| Size | Price | Stock |
|---|---|---|
| 5mg | $88 | In-stock |
| 10mg | $154 | In-stock |
| 20mg | $253 | In-stock |
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| 100 mg | Get quote | |
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| Cat. No. : | HY-N1381 |
| M.Wt: | 696.82 |
| Formula: | C36H56O13 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Periplocin is a cardiotonic steroid isolated from root-bark Periploca sepium Bunge. Periplocin promotes tumor cell apoptosis and inhibits tumor growth. Periplocin has the potential to facilitate wound healing through the activation of Src/ERK and PI3K/Akt pathways mediated by Na/K-ATPase[1][2].
IC50 & Target:Apoptosis[2]
In Vitro: Periplocin (5-20 μM; 48 hours; L929 cells) treatment shows increased proliferation up to 131% at 20 μM[1].
Periplocin (5-20 μM; 30-120 minutes; L929 cells) increases phosphorylation of Src, ERK, PI3K and Akt at active sites in a dosedependent and time-dependent manner.
Periplocin (5-20 μM; 48 hours) significantly promotes migration of fibroblast cell[1].
Periplocin (5-20 μM; 48 hours) increases collagen production in L929 fibroblast[1].
Periplocin induces Na/KATPase mediates the activation of Src/ERK and PI3K/Akt pathways[1].
In Vivo: Periplocin (5-20 mg/kg; intraperitoneal injection; daily; for 14 days; female SCID mice) treatment represses the growth of hepatocellular carcinoma (HCC) in xenograft tumor model in mice[2].
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