Fludioxonil

Fludioxonil (CGA-173506) is a phenylpyrrole-type fungicide with oral activity that can inhibit the growth of S. sclerotiorum. Fludioxonil promotes tumor growth and metastasis, and induces cardiac toxicity. Fludioxonil causes cytoskeletal disruption, DNA damage, and apoptosis in mouse glioma cells^[1][2][3][4]. In Vitro:Fludioxonil with EC₅₀ of Fludioxonil for HA61, NT18 and SZ45 are 0.0039, 0.0118 and 0.018 lg/mL^[1].
Fludioxonil has a strong inhibitory effect on hyphal growth^[1].
Fludioxonil (10 nM-10 μM, 9 days) promots the proliferation of MCF-7 CV cells^[2].
Fludioxonil (10 μM, 72 h) reduces the expression of p21 and E-cadherin proteins in MCF-7 CV cells^[2].
Fludioxonil (10 μM, 72 h) promotes the migration of MCF-7 CV cells^[2].
Fludioxonil inhibits F98 cells with an IC₅₀ of 40μM^[3].
Fludioxonil (10-40 μM, 24 h) increases ROS levels in F98 cells and induces lipid peroxidation and cell cycle arrest^[3].
Fludioxonil (10-40 μM, 24 h) treatment induces DNA fragmentation in F98 cells^[3].
Fludioxonil (10-40 μM, 24 h) treatment induces apoptosis in F98 cells^[3]. In Vivo:Fludioxonil (40 mg/kg, i.g., once every three days for 80 days) inhibits tumor proliferation in mice^[2].