FT-1518
CAS No. : 1313026-58-2
| Size | Price | Stock |
|---|---|---|
| 5mg | $130 | In-stock |
| 10mg | $210 | In-stock |
| 25mg | $420 | In-stock |
| 50mg | $680 | In-stock |
| 100mg | $1100 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-107363 |
| M.Wt: | 394.47 |
| Formula: | C20H26N8O |
| Purity: | >98 % |
| Solubility: | DMSO : 5 mg/mL (ultrasonic;warming;heat to 60°C) |
FT-1518 is a new generation selective, potent and oral bioavailable mTORC1 and mTORC2 inhibitor, and exhibits antitumor activity. IC50 & Target: mTORC1, mTORC2[1] In Vitro: FT-1518 is a new generation selective, potent and oral bioavailable mTORC1 and mTORC2 inhibitor, and exhibits antitumor activity. FT-1518 displays significant growth inhibitory activity against a large panel of hematologic and solid tumor cell lines with most activities falling into low nanomolar range. FT-1518 cuases potent inhibition of the mTOR pathway biomarkers (mTORC 1 & 2 biomarkers [pAkt(S473) and pS6(S240/244) or p70 S6K), no inhibition of PI3K biomarker [pAkt(T308)] in cells[1]. In Vivo: FT-1518 exhibits dose-dependent and higher tumor growth inhibition (TGI) in multiple solid tumor xenografts[1].
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