LXW7
CAS No. : 1313004-77-1
| Size | Price | Stock |
|---|---|---|
| 1mg | $50 | In-stock |
| 5mg | $150 | In-stock |
| 10mg | $240 | In-stock |
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| Cat. No. : | HY-P0178 |
| M.Wt: | 820.89 |
| Formula: | C29H48N12O12S2 |
| Purity: | >98 % |
| Solubility: | H2O |
LXW7, a cyclic peptide containing Arg-Gly-Asp (RGD), is an integrin αvβ3 inhibitor. LXW7 has a high binding affinity to αvβ3 integrin with an IC50 of 0.68 μM. LXW7 increases phosphorylation of VEGFR-2 and activation of ERK1/2. Anti-inflammatory effect[1][2][3].
IC50 & Target:IC50: 0.68 μM (αvβ3 integrin)[1]
In Vitro: LXW7 specially binds to αvβ3 integrin (Kd=76±10 nM). LXW7 binds strongly to αvβ3-K562 cells, weakly to αvβ5-K562 cells and αIIbβ3-K562 cells, and no binding to K562 cells. LXW7 has great potential as a highly efficient peptide ligand for targeted imaging and drug delivery[1].
LXW7 acts as a potent and specific endothelial progenitor cells (EPCs) and endothelial cells (ECs) targeting ligand[2].
In Vivo: LXW7 (100 μg/kg; intravenous injection) significantly lowers infarct volumes and brain water content (BWC) LXW7-treated rats. The LXW7 treatment lowers the expression of pro-inflammatory cytokines[3].
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