Ro 25-6981 (Maleate)
CAS No. : 1312991-76-6
| Size | Price | Stock |
|---|---|---|
| 5mg | $96 | In-stock |
| 10mg | $138 | In-stock |
| 25mg | $275 | In-stock |
| 50mg | $480 | In-stock |
| 100mg | $900 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-13993A |
| M.Wt: | 455.54 |
| Formula: | C26H33NO6 |
| Purity: | >98 % |
| Solubility: | H2O : 8.33 mg/mL (ultrasonic;warming;heat to 45°C);DMSO : 100 mg/mL (ultrasonic) |
Ro 25-6981 Maleate is a potent, selective and activity-dependent NR2B subunit specific NMDA receptor antagonist. Ro 25-6981 Maleat shows anticonvulsant and anti-parkinsonian activity. Ro 25-6981 Maleate has the potential for the research of parkinson's disease (PD)[1][2][3].
In Vivo:Ro 25-6981 Maleate (0.39-12.5 mg/kg; i.p.) induces contraversive rotations in 6-hydroxydopamine (6-OHDA)-lesioned rats without stimulating locomotion in normal rats[1].
Ro 25-6981 Maleate (1,3 mg/kg; i.p.) exhibits age- and activation-dependent anticonvulsant action at early postnatal development in rats[2].
Ro 25-6981 Maleate (800 μg; intrathecal injection) shows significant analgesic effects on incision pain in rats and effectively attenuated postoperative hyperalgesia induced by remifentanil[3].
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