Efaproxiral
CAS No. : 131179-95-8
(Synonyms: RSR13)
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| Cat. No. : | HY-13619 |
| M.Wt: | 341.40 |
| Formula: | C20H23NO4 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 150 mg/mL |
Efaproxiral is a haemoglobin (Hb) synthetic allosteric modifier, decreases Hb-oxygen (O2) binding affinity and enhances oxygenation of hypoxic tumours during radiation therapy [1].
IC50 & Target: haemoglobin (Hb)[1]
In Vitro: Efaproxiral binds to only one pair of symmetry-related sites in the Hb central water cavity[2].
Efaproxiral readily crosses the red cell membrane in the presence of serum albumin solutions[2].
Efaproxiral is not inhibited from entering erythrocytes in the presence of an anion-channel blocking agent (DIDS)[2].
In Vivo: Efaproxiral (150 mg/kg, i.p.) increase tumor oxygenation，and increase the tumor growth inhibition of radiotherapy over 5 days of treatment[3].
Efaproxiral reduces hemoglobin-oxygen binding affinity, which facilitates oxygen release from hemoglobin into surrounding tissues and potentially increases the pO(2) of the tumors[4]
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