NSC624206
CAS No. : 13116-77-3
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| 5mg | $360 | In-stock |
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| Cat. No. : | HY-103436 |
| M.Wt: | 410.51 |
| Formula: | C19H33Cl2NS2 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
NSC624206 is an inhibitor of ubiquitin E1 (UBA1), with an IC50 of ~9 μM. NSC624206 specifically blocks ubiquitin-thioester formation (IC50=13 μM) but has no effect on ubiquitin adenylation[1].
IC50 & Target: IC50: ~9 μM (ubiquitin E1)[1]
In Vitro: NSC624206 prevents in vitro ubiquitination of the cell cycle regulator p27 as well as inducing an accumulation of p27 in the HepG2 liver cancer cell line[1].
NSC624206 clearly reduces ubiquitin-E1 thioesters in a concentration-dependent manner with an IC50 of 13 μM[1].
NSC624206 (10 nM-10 μM; 24 hours) induces accumulation of p27 in cells[1].
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