YF-2
CAS No. : 1311423-89-8
| Size | Price | Stock |
|---|---|---|
| 5mg | $150 | In-stock |
| 10mg | $240 | In-stock |
| 25mg | $500 | In-stock |
| 50mg | $850 | In-stock |
| 100mg | $1360 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-16531 |
| M.Wt: | 430.85 |
| Formula: | C20H22ClF3N2O3 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 125 mg/mL |
YF-2 is a highly selective, blood-brain-barrier permeable histone acetyltransferase activator, acetylates H3 in the hippocampus, with EC50s of 2.75 μM, 29.04 μM and 49.31 μM for CBP, PCAF, and GCN5, respectively, shows no effect on HDAC. Anti-cancer and anti-Alzheimer's disease[1]. IC50 & Target:EC50: 2.75 μM (CBP), 29.04 μM (PCAF), 49.31 μM (GCN5)[1] In Vitro:YF-2 (0.03, 0.1, 0.25, 0.5, 1, 2.5, 5, 15, 40 and 80 μM, 72 hours) inhibits the preliferation of U251, CCRF-CEM, Hs578T, NCI-ADR-RES cells[1]. In Vivo:YF-2 (20 mg/kg, 2 hours befor electric shock or 5 mg/kg, 30 min before the electric shock, i.p.) rescues the defect in contextual memory in mice, and shows no effect on contextual memory alone at 20 mg/kg in mice[1].
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